Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4643414..4643930 Replicon chromosome
Accession NZ_CP030311
Organism Klebsiella pneumoniae strain 11454

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag DRA80_RS22355 Protein ID WP_004178374.1
Coordinates 4643414..4643698 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DRA80_RS22360 Protein ID WP_002886901.1
Coordinates 4643688..4643930 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRA80_RS22330 (4638897) 4638897..4639160 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
DRA80_RS22335 (4639290) 4639290..4639463 + 174 WP_004210630.1 hypothetical protein -
DRA80_RS22340 (4639466) 4639466..4640209 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
DRA80_RS22345 (4640566) 4640566..4642704 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
DRA80_RS22350 (4642946) 4642946..4643410 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DRA80_RS22355 (4643414) 4643414..4643698 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DRA80_RS22360 (4643688) 4643688..4643930 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DRA80_RS22365 (4644008) 4644008..4645918 - 1911 WP_004152270.1 PRD domain-containing protein -
DRA80_RS22370 (4645941) 4645941..4647095 - 1155 WP_004210635.1 lactonase family protein -
DRA80_RS22375 (4647162) 4647162..4647902 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T107604 WP_004178374.1 NZ_CP030311:c4643698-4643414 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T107604 NZ_CP030311:c4643698-4643414 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT107604 WP_002886901.1 NZ_CP030311:c4643930-4643688 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT107604 NZ_CP030311:c4643930-4643688 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References