Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3928490..3929109 Replicon chromosome
Accession NZ_CP030311
Organism Klebsiella pneumoniae strain 11454

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DRA80_RS18980 Protein ID WP_002892050.1
Coordinates 3928891..3929109 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DRA80_RS18975 Protein ID WP_002892066.1
Coordinates 3928490..3928864 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRA80_RS18965 (3923642) 3923642..3924835 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DRA80_RS18970 (3924858) 3924858..3928004 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
DRA80_RS18975 (3928490) 3928490..3928864 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DRA80_RS18980 (3928891) 3928891..3929109 + 219 WP_002892050.1 HHA domain-containing protein Toxin
DRA80_RS18985 (3929268) 3929268..3929834 + 567 WP_002892030.1 maltose O-acetyltransferase -
DRA80_RS18990 (3929806) 3929806..3929946 - 141 WP_004147370.1 hypothetical protein -
DRA80_RS18995 (3929967) 3929967..3930437 + 471 WP_002892026.1 YlaC family protein -
DRA80_RS19000 (3930412) 3930412..3931863 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
DRA80_RS19005 (3931964) 3931964..3932662 + 699 WP_004177238.1 GNAT family protein -
DRA80_RS19010 (3932659) 3932659..3932799 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DRA80_RS19015 (3932799) 3932799..3933062 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107602 WP_002892050.1 NZ_CP030311:3928891-3929109 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T107602 NZ_CP030311:3928891-3929109 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT107602 WP_002892066.1 NZ_CP030311:3928490-3928864 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT107602 NZ_CP030311:3928490-3928864 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References