Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3939057..3939676 Replicon chromosome
Accession NZ_CP030302
Organism Klebsiella pneumoniae strain 205880

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DRB04_RS19205 Protein ID WP_002892050.1
Coordinates 3939458..3939676 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DRB04_RS19200 Protein ID WP_002892066.1
Coordinates 3939057..3939431 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB04_RS19190 (DRB04_19620) 3934209..3935402 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DRB04_RS19195 (DRB04_19625) 3935425..3938571 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
DRB04_RS19200 (DRB04_19630) 3939057..3939431 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DRB04_RS19205 (DRB04_19635) 3939458..3939676 + 219 WP_002892050.1 HHA domain-containing protein Toxin
DRB04_RS19210 (DRB04_19640) 3939835..3940401 + 567 WP_065888843.1 maltose O-acetyltransferase -
DRB04_RS19215 3940373..3940513 - 141 WP_032409038.1 hypothetical protein -
DRB04_RS19220 (DRB04_19645) 3940534..3941004 + 471 WP_002892026.1 YlaC family protein -
DRB04_RS19225 (DRB04_19650) 3940979..3942430 - 1452 WP_065888842.1 PLP-dependent aminotransferase family protein -
DRB04_RS19230 (DRB04_19655) 3942531..3943229 + 699 WP_002892021.1 GNAT family protein -
DRB04_RS19235 (DRB04_19660) 3943226..3943366 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DRB04_RS19240 (DRB04_19665) 3943366..3943629 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107575 WP_002892050.1 NZ_CP030302:3939458-3939676 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T107575 NZ_CP030302:3939458-3939676 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT107575 WP_002892066.1 NZ_CP030302:3939057-3939431 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT107575 NZ_CP030302:3939057-3939431 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References