Detailed information of TA system TA107564

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 794066..794723
• Replicon: chromosome
• Accession: NZ_CP030302
• Organism: Klebsiella pneumoniae strain 205880

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DRB04_RS03945
• Protein ID: WP_040245400.1
• Coordinates: 794313..794723 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: DRB04_RS03940
• Protein ID: WP_002916312.1
• Coordinates: 794066..794332 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRB04_RS03915 (DRB04_04035)	789222..790655	-	1434	WP_065888469.1	6-phospho-beta-glucosidase	-
DRB04_RS03920 (DRB04_04040)	790774..791502	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
DRB04_RS03925 (DRB04_04045)	791552..791863	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
DRB04_RS03930 (DRB04_04050)	792027..792686	+	660	WP_048334397.1	hemolysin III family protein	-
DRB04_RS03935 (DRB04_04055)	792837..793820	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
DRB04_RS03940 (DRB04_04060)	794066..794332	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
DRB04_RS03945 (DRB04_04065)	794313..794723	+	411	WP_040245400.1	protein YgfX	Toxin
DRB04_RS03950 (DRB04_04070)	794730..795251	-	522	WP_002916308.1	flavodoxin FldB	-
DRB04_RS03955 (DRB04_04075)	795352..796248	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
DRB04_RS03960 (DRB04_04080)	796271..796984	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DRB04_RS03965 (DRB04_04085)	796990..798723	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T107564 WP_040245400.1 NZ_CP030302:794313-794723 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T107564 NZ_CP030302:794313-794723 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT107564 WP_002916312.1 NZ_CP030302:794066-794332 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT107564 NZ_CP030302:794066-794332 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41