Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4718242..4718758 Replicon chromosome
Accession NZ_CP030296
Organism Klebsiella pneumoniae strain 309074

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag DQG43_RS22980 Protein ID WP_004178374.1
Coordinates 4718242..4718526 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DQG43_RS22985 Protein ID WP_002886901.1
Coordinates 4718516..4718758 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQG43_RS22955 (4713637) 4713637..4713900 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
DQG43_RS22960 (4714030) 4714030..4714203 + 174 WP_032412860.1 hypothetical protein -
DQG43_RS22965 (4714206) 4714206..4714949 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
DQG43_RS22970 (4715306) 4715306..4717444 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
DQG43_RS22975 (4717774) 4717774..4718238 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DQG43_RS22980 (4718242) 4718242..4718526 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQG43_RS22985 (4718516) 4718516..4718758 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQG43_RS22990 (4718836) 4718836..4720746 - 1911 WP_004152270.1 PRD domain-containing protein -
DQG43_RS22995 (4720769) 4720769..4721923 - 1155 WP_002886900.1 lactonase family protein -
DQG43_RS23000 (4721990) 4721990..4722730 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T107526 WP_004178374.1 NZ_CP030296:c4718526-4718242 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T107526 NZ_CP030296:c4718526-4718242 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT107526 WP_002886901.1 NZ_CP030296:c4718758-4718516 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT107526 NZ_CP030296:c4718758-4718516 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References