Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832975..833632 Replicon chromosome
Accession NZ_CP030296
Organism Klebsiella pneumoniae strain 309074

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DQG43_RS04110 Protein ID WP_002916310.1
Coordinates 833222..833632 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DQG43_RS04105 Protein ID WP_002916312.1
Coordinates 832975..833241 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQG43_RS04080 (828131) 828131..829564 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
DQG43_RS04085 (829683) 829683..830411 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DQG43_RS04090 (830461) 830461..830772 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
DQG43_RS04095 (830936) 830936..831595 + 660 WP_002916317.1 hemolysin III family protein -
DQG43_RS04100 (831746) 831746..832729 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
DQG43_RS04105 (832975) 832975..833241 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DQG43_RS04110 (833222) 833222..833632 + 411 WP_002916310.1 protein YgfX Toxin
DQG43_RS04115 (833639) 833639..834160 - 522 WP_004144730.1 flavodoxin FldB -
DQG43_RS04120 (834261) 834261..835157 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DQG43_RS04125 (835180) 835180..835893 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DQG43_RS04130 (835899) 835899..837632 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T107514 WP_002916310.1 NZ_CP030296:833222-833632 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T107514 NZ_CP030296:833222-833632 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT107514 WP_002916312.1 NZ_CP030296:832975-833241 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT107514 NZ_CP030296:832975-833241 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References