107506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 41189..41715 Replicon plasmid p721005-1
Accession NZ_CP030293
Organism Klebsiella pneumoniae strain 721005

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DRB00_RS27235 Protein ID WP_000323025.1
Coordinates 41428..41715 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DRB00_RS27230 Protein ID WP_000534858.1
Coordinates 41189..41428 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB00_RS27210 (DRB00_28105) 37187..38527 + 1341 WP_000589001.1 ISNCY family transposase -
DRB00_RS27215 (DRB00_28110) 38948..39259 + 312 Protein_45 transposase -
DRB00_RS27225 (DRB00_28125) 40510..40926 + 417 Protein_47 cation-efflux pump -
DRB00_RS29965 41060..41164 - 105 Protein_48 hypothetical protein -
DRB00_RS27230 (DRB00_28135) 41189..41428 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DRB00_RS27235 (DRB00_28140) 41428..41715 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DRB00_RS27240 (DRB00_28145) 41787..41945 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
DRB00_RS27245 42548..43522 + 975 WP_004181899.1 hypothetical protein -
DRB00_RS27250 (DRB00_28160) 43720..44097 - 378 WP_004181901.1 hypothetical protein -
DRB00_RS27255 (DRB00_28175) 44787..45854 + 1068 WP_004181903.1 hypothetical protein -
DRB00_RS27260 (DRB00_28180) 46010..46357 + 348 WP_004181904.1 hypothetical protein -
DRB00_RS27265 (DRB00_28185) 46436..46669 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iucA / iucB / iucC / iucD / iutA / rmpA 1..269204 269204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T107506 WP_000323025.1 NZ_CP030293:41428-41715 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T107506 NZ_CP030293:41428-41715 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT107506 WP_000534858.1 NZ_CP030293:41189-41428 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT107506 NZ_CP030293:41189-41428 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References