Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4218273..4218892 Replicon chromosome
Accession NZ_CP030292
Organism Klebsiella pneumoniae strain 721005

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DRB00_RS20960 Protein ID WP_002892050.1
Coordinates 4218674..4218892 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DRB00_RS20955 Protein ID WP_002892066.1
Coordinates 4218273..4218647 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB00_RS20945 (DRB00_21525) 4213425..4214618 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DRB00_RS20950 (DRB00_21530) 4214641..4217787 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
DRB00_RS20955 (DRB00_21535) 4218273..4218647 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DRB00_RS20960 (DRB00_21540) 4218674..4218892 + 219 WP_002892050.1 HHA domain-containing protein Toxin
DRB00_RS20965 (DRB00_21545) 4219051..4219617 + 567 WP_002892030.1 maltose O-acetyltransferase -
DRB00_RS20970 4219589..4219729 - 141 WP_004147370.1 hypothetical protein -
DRB00_RS20975 (DRB00_21550) 4219750..4220220 + 471 WP_002892026.1 YlaC family protein -
DRB00_RS20980 (DRB00_21555) 4220195..4221646 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
DRB00_RS20985 (DRB00_21560) 4221747..4222445 + 699 WP_002892021.1 GNAT family protein -
DRB00_RS20990 (DRB00_21565) 4222442..4222582 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DRB00_RS20995 (DRB00_21570) 4222582..4222845 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107500 WP_002892050.1 NZ_CP030292:4218674-4218892 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T107500 NZ_CP030292:4218674-4218892 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT107500 WP_002892066.1 NZ_CP030292:4218273-4218647 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT107500 NZ_CP030292:4218273-4218647 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References