Detailed information of TA system TA107487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 77649..78292
• Replicon: plasmid pIncI1.1
• Accession: NZ_CP030289
• Organism: Salmonella enterica subsp. enterica serovar Gaminara str. SA20063285

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: LFZ12_RS25285
• Protein ID: WP_058112046.1
• Coordinates: 77876..78292 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A8F2UWJ1
• Locus tag: LFZ12_RS25280
• Protein ID: WP_001261289.1
• Coordinates: 77649..77879 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ12_RS25790	72795..72947	+	153	WP_001838496.1	hypothetical protein	-
LFZ12_RS25250	73562..74257	-	696	WP_000389613.1	CPBP family intramembrane metalloprotease	-
LFZ12_RS25255	74760..75542	-	783	WP_058112048.1	site-specific integrase	-
LFZ12_RS25260	75555..76089	-	535	Protein_76	cytoplasmic protein	-
LFZ12_RS25265	76086..76376	-	291	WP_058112047.1	cytoplasmic protein	-
LFZ12_RS25270	76378..76683	-	306	WP_001159874.1	type II toxin-antitoxin system toxin CcdB	-
LFZ12_RS25275	76685..76903	-	219	WP_000813642.1	type II toxin-antitoxin system antitoxin CcdA	-
LFZ12_RS25280	77649..77879	+	231	WP_001261289.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LFZ12_RS25285	77876..78292	+	417	WP_058112046.1	type II toxin-antitoxin system VapC family toxin	Toxin
LFZ12_RS25290	78338..82132	-	3795	WP_023180558.1	hypothetical protein	-
LFZ12_RS25300	82480..82725	+	246	WP_000368360.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..117908	117908

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 17834.22 Da
• Isoelectric Point: 12.9398

>T107487 WP_058112046.1 NZ_CP030289:77876-78292 [Salmonella enterica subsp. enterica serovar Gaminara str.]
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KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 417 bp

>T107487 NZ_CP030289:77876-78292 [Salmonella enterica subsp. enterica serovar Gaminara str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9887.42 Da
• Isoelectric Point: 12.6808

>AT107487 WP_001261289.1 NZ_CP030289:77649-77879 [Salmonella enterica subsp. enterica serovar Gaminara str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 231 bp

>AT107487 NZ_CP030289:77649-77879 [Salmonella enterica subsp. enterica serovar Gaminara str.]
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AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA