Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 76378..76903 Replicon plasmid pIncI1.1
Accession NZ_CP030289
Organism Salmonella enterica subsp. enterica serovar Gaminara str. SA20063285

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag LFZ12_RS25270 Protein ID WP_001159874.1
Coordinates 76378..76683 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag LFZ12_RS25275 Protein ID WP_000813642.1
Coordinates 76685..76903 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ12_RS25790 72795..72947 + 153 WP_001838496.1 hypothetical protein -
LFZ12_RS25250 73562..74257 - 696 WP_000389613.1 CPBP family intramembrane metalloprotease -
LFZ12_RS25255 74760..75542 - 783 WP_058112048.1 site-specific integrase -
LFZ12_RS25260 75555..76089 - 535 Protein_76 cytoplasmic protein -
LFZ12_RS25265 76086..76376 - 291 WP_058112047.1 cytoplasmic protein -
LFZ12_RS25270 76378..76683 - 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
LFZ12_RS25275 76685..76903 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LFZ12_RS25280 77649..77879 + 231 WP_001261289.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LFZ12_RS25285 77876..78292 + 417 WP_058112046.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..117908 117908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T107486 WP_001159874.1 NZ_CP030289:c76683-76378 [Salmonella enterica subsp. enterica serovar Gaminara str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T107486 NZ_CP030289:c76683-76378 [Salmonella enterica subsp. enterica serovar Gaminara str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT107486 WP_000813642.1 NZ_CP030289:c76903-76685 [Salmonella enterica subsp. enterica serovar Gaminara str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT107486 NZ_CP030289:c76903-76685 [Salmonella enterica subsp. enterica serovar Gaminara str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References