Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4291790..4292447 Replicon chromosome
Accession NZ_CP030269
Organism Klebsiella pneumoniae subsp. pneumoniae strain SC-7

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DQQ08_RS22180 Protein ID WP_002916310.1
Coordinates 4292037..4292447 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DQQ08_RS22175 Protein ID WP_002916312.1
Coordinates 4291790..4292056 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQQ08_RS22150 4286997..4288430 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
DQQ08_RS22155 4288549..4289277 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
DQQ08_RS22160 4289327..4289638 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DQQ08_RS22165 4289803..4290462 + 660 WP_002916317.1 hemolysin III family protein -
DQQ08_RS22170 4290561..4291544 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
DQQ08_RS22175 4291790..4292056 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DQQ08_RS22180 4292037..4292447 + 411 WP_002916310.1 protein YgfX Toxin
DQQ08_RS22185 4292454..4292975 - 522 WP_002916308.1 flavodoxin FldB -
DQQ08_RS22190 4293076..4293972 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DQQ08_RS22195 4293995..4294708 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DQQ08_RS22200 4294714..4296447 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T107441 WP_002916310.1 NZ_CP030269:4292037-4292447 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T107441 NZ_CP030269:4292037-4292447 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT107441 WP_002916312.1 NZ_CP030269:4291790-4292056 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT107441 NZ_CP030269:4291790-4292056 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References