Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2186868..2187487 Replicon chromosome
Accession NZ_CP030269
Organism Klebsiella pneumoniae subsp. pneumoniae strain SC-7

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DQQ08_RS11680 Protein ID WP_002892050.1
Coordinates 2187269..2187487 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DQQ08_RS11675 Protein ID WP_002892066.1
Coordinates 2186868..2187242 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQQ08_RS11665 2182020..2183213 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DQQ08_RS11670 2183236..2186382 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
DQQ08_RS11675 2186868..2187242 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DQQ08_RS11680 2187269..2187487 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DQQ08_RS11685 2187646..2188212 + 567 WP_002892030.1 maltose O-acetyltransferase -
DQQ08_RS29240 2188184..2188324 - 141 WP_004147370.1 hypothetical protein -
DQQ08_RS11690 2188345..2188815 + 471 WP_002892026.1 YlaC family protein -
DQQ08_RS11695 2188790..2190241 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
DQQ08_RS11700 2190342..2191040 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
DQQ08_RS11705 2191037..2191177 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DQQ08_RS11710 2191177..2191440 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107435 WP_002892050.1 NZ_CP030269:2187269-2187487 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T107435 NZ_CP030269:2187269-2187487 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT107435 WP_002892066.1 NZ_CP030269:2186868-2187242 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT107435 NZ_CP030269:2186868-2187242 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References