Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 853863..854392 Replicon chromosome
Accession NZ_CP030246
Organism Staphylococcus epidermidis strain CSF41498

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag DQW72_RS04140 Protein ID WP_001829891.1
Coordinates 854030..854392 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag DQW72_RS04135 Protein ID WP_001829931.1
Coordinates 853863..854033 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQW72_RS04110 849689..850168 + 480 WP_002457111.1 PH domain-containing protein -
DQW72_RS04115 850161..851666 + 1506 WP_002457110.1 PH domain-containing protein -
DQW72_RS04120 851653..852162 + 510 WP_002457109.1 PH domain-containing protein -
DQW72_RS04125 852210..852563 + 354 WP_002457108.1 holo-ACP synthase -
DQW72_RS04130 852628..853776 + 1149 WP_002457107.1 alanine racemase -
DQW72_RS04135 853863..854033 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQW72_RS04140 854030..854392 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQW72_RS04145 854737..855738 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
DQW72_RS04150 855838..856164 + 327 WP_001829952.1 anti-sigma factor antagonist -
DQW72_RS04155 856166..856645 + 480 WP_001829903.1 anti-sigma B factor RsbW -
DQW72_RS04160 856620..857390 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T107412 WP_001829891.1 NZ_CP030246:854030-854392 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T107412 NZ_CP030246:854030-854392 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT107412 WP_001829931.1 NZ_CP030246:853863-854033 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT107412 NZ_CP030246:853863-854033 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0


Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References