Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 842681..843190 Replicon chromosome
Accession NZ_CP030246
Organism Staphylococcus epidermidis strain CSF41498

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag DQW72_RS04080 Protein ID WP_001829980.1
Coordinates 842981..843190 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag DQW72_RS04075 Protein ID WP_001829893.1
Coordinates 842681..842974 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQW72_RS04050 837689..838477 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
DQW72_RS04055 838483..839121 + 639 WP_002505076.1 thiamine phosphate synthase -
DQW72_RS04060 839210..840082 + 873 WP_002458703.1 membrane protein insertase YidC -
DQW72_RS04065 840188..840841 - 654 WP_001829983.1 HD domain-containing protein -
DQW72_RS04070 841023..842507 - 1485 WP_002457116.1 cardiolipin synthase -
DQW72_RS04075 842681..842974 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQW72_RS04080 842981..843190 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
DQW72_RS04085 843333..843470 + 138 WP_001829949.1 hypothetical protein -
DQW72_RS04090 843569..844780 - 1212 WP_002486299.1 rod shape-determining protein RodA -
DQW72_RS04095 845171..846244 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
DQW72_RS04100 846256..847611 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T107411 WP_001829980.1 NZ_CP030246:842981-843190 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T107411 NZ_CP030246:842981-843190 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT107411 WP_001829893.1 NZ_CP030246:842681-842974 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT107411 NZ_CP030246:842681-842974 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References