Detailed information of TA system TA107409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1035671..1036223
• Replicon: chromosome
• Accession: NZ_CP030241
• Organism: Moraxella bovis strain Epp63 (300)

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: DQF64_RS05485
• Protein ID: WP_029102268.1
• Coordinates: 1035945..1036223 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: DQF64_RS05480
• Protein ID: WP_078273473.1
• Coordinates: 1035671..1035958 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQF64_RS05465	1031106..1032155	+	1050	WP_112742119.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
DQF64_RS05470	1032234..1033733	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
DQF64_RS05475	1033931..1035661	-	1731	WP_078273474.1	flotillin	-
DQF64_RS05480	1035671..1035958	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
DQF64_RS05485	1035945..1036223	-	279	WP_029102268.1	BrnT family toxin	Toxin
DQF64_RS05490	1036318..1036974	-	657	WP_078273472.1	YqiJ family protein	-
DQF64_RS05495	1037174..1037839	-	666	WP_078273471.1	PspA/IM30 family protein	-
DQF64_RS05500	1038052..1038342	-	291	WP_078273470.1	hypothetical protein	-
DQF64_RS05505	1038335..1038850	-	516	WP_078273469.1	hypothetical protein	-
DQF64_RS05510	1038998..1039348	-	351	WP_078273468.1	TIGR01244 family phosphatase	-
DQF64_RS05515	1039460..1040236	+	777	WP_078273467.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T107409 WP_029102268.1 NZ_CP030241:c1036223-1035945 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T107409 NZ_CP030241:c1036223-1035945 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT107409 WP_078273473.1 NZ_CP030241:c1035958-1035671 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT107409 NZ_CP030241:c1035958-1035671 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3