Detailed information of TA system TA107405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 552689..553347
• Replicon: chromosome
• Accession: NZ_CP030241
• Organism: Moraxella bovis strain Epp63 (300)

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DQF64_RS02840
• Protein ID: WP_078274940.1
• Coordinates: 552689..552877 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DQF64_RS02845
• Protein ID: WP_112741846.1
• Coordinates: 552940..553347 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQF64_RS02790	547926..548618	+	693	WP_112741843.1	DUF2786 domain-containing protein	-
DQF64_RS02795	548698..548940	+	243	WP_162860345.1	hypothetical protein	-
DQF64_RS02800	549093..549314	+	222	WP_036387886.1	hypothetical protein	-
DQF64_RS02805	549357..549569	+	213	WP_112741803.1	helix-turn-helix domain-containing protein	-
DQF64_RS02810	549651..550076	+	426	WP_112741845.1	peptidase M15	-
DQF64_RS02815	550154..550906	+	753	WP_078274945.1	hypothetical protein	-
DQF64_RS02820	550950..551294	-	345	WP_078274944.1	helix-turn-helix domain-containing protein	-
DQF64_RS02825	551417..551623	+	207	WP_078274943.1	hypothetical protein	-
DQF64_RS02830	551730..552329	+	600	WP_078274942.1	antA/AntB antirepressor family protein	-
DQF64_RS02835	552331..552546	+	216	WP_078274941.1	hypothetical protein	-
DQF64_RS02840	552689..552877	+	189	WP_078274940.1	type II toxin-antitoxin system HicA family toxin	Toxin
DQF64_RS02845	552940..553347	+	408	WP_112741846.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DQF64_RS02850	553423..554394	+	972	WP_112741847.1	phage tail tape measure protein	-
DQF64_RS02855	554391..554723	+	333	WP_112741848.1	hypothetical protein	-
DQF64_RS02860	554657..555094	+	438	WP_162860346.1	hypothetical protein	-
DQF64_RS02865	555148..555954	+	807	WP_112741850.1	hypothetical protein	-
DQF64_RS02870	555955..556299	+	345	WP_078274937.1	hypothetical protein	-
DQF64_RS02875	556287..558116	+	1830	WP_078274936.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	543886..563365	19479

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7047.13 Da
• Isoelectric Point: 10.3659

>T107405 WP_078274940.1 NZ_CP030241:552689-552877 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Nucleotide

• Length: 189 bp

>T107405 NZ_CP030241:552689-552877 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14756.85 Da
• Isoelectric Point: 4.2244

>AT107405 WP_112741846.1 NZ_CP030241:552940-553347 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Nucleotide

• Length: 408 bp

>AT107405 NZ_CP030241:552940-553347 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG