Detailed information of TA system TA107404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 436543..437195
• Replicon: chromosome
• Accession: NZ_CP030241
• Organism: Moraxella bovis strain Epp63 (300)

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DQF64_RS02205
• Protein ID: WP_078275188.1
• Coordinates: 436803..437195 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DQF64_RS02200
• Protein ID: WP_078275189.1
• Coordinates: 436543..436806 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQF64_RS02170	431860..433194	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
DQF64_RS02175	433338..433631	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
DQF64_RS02180	433645..433896	+	252	WP_078275201.1	type II toxin-antitoxin system YafQ family toxin	-
DQF64_RS02185	433961..434401	-	441	WP_208624064.1	type IV secretion protein Rhs	-
DQF64_RS02190	434452..435225	+	774	WP_078275191.1	hypothetical protein	-
DQF64_RS02195	435204..436463	+	1260	WP_078275190.1	replication-associated recombination protein A	-
DQF64_RS02200	436543..436806	+	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DQF64_RS02205	436803..437195	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
DQF64_RS02210	437318..437848	+	531	WP_078275187.1	hypothetical protein	-
DQF64_RS02215	437845..438411	-	567	WP_078275186.1	hypothetical protein	-
DQF64_RS02220	438414..438650	-	237	WP_078275185.1	sulfurtransferase TusA	-
DQF64_RS02225	438647..439105	-	459	WP_078275184.1	acyl-CoA thioesterase	-
DQF64_RS02230	439185..440207	-	1023	WP_078275183.1	hypothetical protein	-
DQF64_RS02235	440238..441116	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
DQF64_RS02240	441162..442103	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T107404 WP_078275188.1 NZ_CP030241:436803-437195 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T107404 NZ_CP030241:436803-437195 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTTTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10183.52 Da
• Isoelectric Point: 6.3724

>AT107404 WP_078275189.1 NZ_CP030241:436543-436806 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKTFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT107404 NZ_CP030241:436543-436806 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAACCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA