Detailed information of TA system TA107403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 433338..433896
• Replicon: chromosome
• Accession: NZ_CP030241
• Organism: Moraxella bovis strain Epp63 (300)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DQF64_RS02180
• Protein ID: WP_078275201.1
• Coordinates: 433645..433896 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: DQF64_RS02175
• Protein ID: WP_029103533.1
• Coordinates: 433338..433631 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQF64_RS02155	428879..430183	-	1305	WP_112741793.1	valine--pyruvate transaminase	-
DQF64_RS02160	430303..430914	+	612	WP_112741794.1	methyltransferase	-
DQF64_RS02165	430935..431651	+	717	WP_078275193.1	hypothetical protein	-
DQF64_RS02170	431860..433194	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
DQF64_RS02175	433338..433631	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DQF64_RS02180	433645..433896	+	252	WP_078275201.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DQF64_RS02185	433961..434401	-	441	WP_208624064.1	type IV secretion protein Rhs	-
DQF64_RS02190	434452..435225	+	774	WP_078275191.1	hypothetical protein	-
DQF64_RS02195	435204..436463	+	1260	WP_078275190.1	replication-associated recombination protein A	-
DQF64_RS02200	436543..436806	+	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
DQF64_RS02205	436803..437195	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
DQF64_RS02210	437318..437848	+	531	WP_078275187.1	hypothetical protein	-
DQF64_RS02215	437845..438411	-	567	WP_078275186.1	hypothetical protein	-
DQF64_RS02220	438414..438650	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9598.04 Da
• Isoelectric Point: 6.6331

>T107403 WP_078275201.1 NZ_CP030241:433645-433896 [Moraxella bovis]
MGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELHRLATHSE
LFG

Nucleotide

• Length: 252 bp

>T107403 NZ_CP030241:433645-433896 [Moraxella bovis]
ATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGCGTGGACGGAAGTGTCTGATTG
CTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATTGGGTGGGGTTTAGAGATTGTC
ATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACATCGGCTTGCCACGCATAGCGAG
TTGTTTGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT107403 WP_029103533.1 NZ_CP030241:433338-433631 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT107403 NZ_CP030241:433338-433631 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACTCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6