Detailed information of TA system TA107359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 92144..92827
• Replicon: chromosome
• Accession: NZ_CP030239
• Organism: Paracoccus mutanolyticus strain RSP-02

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DPM13_RS00470
• Protein ID: WP_112887237.1
• Coordinates: 92144..92572 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DPM13_RS00475
• Protein ID: WP_080620421.1
• Coordinates: 92576..92827 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPM13_RS00440	87432..87947	+	516	WP_112887233.1	hypothetical protein	-
DPM13_RS19450	88110..88310	+	201	WP_145963275.1	hypothetical protein	-
DPM13_RS00445	88699..88806	+	108	Protein_84	nitronate monooxygenase	-
DPM13_RS00450	89318..89617	-	300	WP_112887234.1	hypothetical protein	-
DPM13_RS20175	89622..89963	-	342	WP_189654785.1	hypothetical protein	-
DPM13_RS00455	90109..90753	+	645	WP_189654786.1	ATP-binding protein	-
DPM13_RS20180	90873..91196	-	324	WP_112887236.1	hypothetical protein	-
DPM13_RS20185	91468..91641	+	174	WP_189654787.1	hypothetical protein	-
DPM13_RS00465	91665..91899	-	235	Protein_90	transposase	-
DPM13_RS00470	92144..92572	-	429	WP_112887237.1	PIN domain-containing protein	Toxin
DPM13_RS00475	92576..92827	-	252	WP_080620421.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DPM13_RS00480	92824..93072	-	249	Protein_93	DUF3363 domain-containing protein	-
DPM13_RS00485	93536..94199	-	664	Protein_94	transposase	-
DPM13_RS00490	94390..94827	-	438	WP_112887238.1	SDR family oxidoreductase	-
DPM13_RS00495	94844..94993	-	150	Protein_96	ABC transporter permease	-
DPM13_RS00500	95832..95999	+	168	Protein_97	IS110 family transposase	-
DPM13_RS20190	96105..96542	+	438	WP_189654788.1	hypothetical protein	-
DPM13_RS00510	96486..96848	-	363	WP_112887239.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	74777..128266	53489

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-65)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15212.44 Da
• Isoelectric Point: 7.4675

>T107359 WP_112887237.1 NZ_CP030239:c92572-92144 [Paracoccus mutanolyticus]
MYLLDTNIVSASAPTRRDTDVLAAWMRVHSDRLYLSAITIAEIEAGIARAVRIGASSKAPALRRWLAAVEHFYASRILAF
GIEEARQAGAILDQARAHGPGFEDIAIAATAAAHGLTVLTANERHFAPLGVPYANPLKELPA

Nucleotide

• Length: 429 bp

>T107359 NZ_CP030239:c92572-92144 [Paracoccus mutanolyticus]
TTGTACCTGCTCGATACCAACATCGTTTCGGCCTCCGCGCCGACGAGGCGAGACACCGATGTTCTCGCTGCATGGATGCG
CGTCCACAGCGACCGGCTCTATCTCTCGGCCATCACCATCGCCGAGATCGAGGCCGGCATCGCCCGGGCGGTCAGGATCG
GCGCCAGCAGCAAGGCCCCGGCGCTGCGCCGCTGGCTCGCTGCGGTCGAGCATTTCTACGCCAGCCGGATCCTCGCTTTC
GGCATCGAGGAGGCTCGTCAGGCCGGGGCGATCCTCGACCAGGCGCGTGCCCATGGTCCGGGCTTCGAGGACATCGCCAT
CGCGGCGACGGCTGCCGCGCATGGCCTGACGGTGCTGACCGCCAACGAGCGGCATTTCGCGCCGCTCGGCGTGCCCTATG
CAAATCCGCTGAAGGAACTGCCCGCATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9323.69 Da
• Isoelectric Point: 7.0152

>AT107359 WP_080620421.1 NZ_CP030239:c92827-92576 [Paracoccus mutanolyticus]
MKELQLRDAKATLSAVVDQAVAGEPTVITRHGRKEAVLLSFEEWQRISRVPDFADLLLAFPGQPEDIPERTRKPARALRD
TSL

Nucleotide

• Length: 252 bp

>AT107359 NZ_CP030239:c92827-92576 [Paracoccus mutanolyticus]
ATGAAGGAACTCCAGCTCAGGGATGCGAAGGCGACGCTCTCCGCCGTGGTCGATCAGGCCGTGGCCGGCGAGCCGACGGT
CATCACCCGGCACGGCCGCAAGGAGGCGGTGCTGCTCTCCTTCGAGGAATGGCAGCGCATCTCGCGAGTTCCGGATTTCG
CCGACCTGCTGCTGGCCTTTCCCGGCCAGCCGGAGGATATCCCTGAACGCACCCGCAAGCCTGCACGCGCGCTGCGGGAT
ACGAGCCTCTGA