Detailed information of TA system TA107351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 36023..36666
• Replicon: plasmid pSA20075157.1
• Accession: NZ_CP030218
• Organism: Salmonella enterica strain SA20075157

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A0A5U2RIY8
• Locus tag: CHD36_RS24285
• Protein ID: WP_000739001.1
• Coordinates: 36250..36666 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A8F2UWJ1
• Locus tag: CHD36_RS24280
• Protein ID: WP_001261289.1
• Coordinates: 36023..36253 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHD36_RS24810	31169..31321	+	153	WP_001838496.1	hypothetical protein	-
CHD36_RS24245	31934..32629	-	696	WP_000389613.1	CPBP family intramembrane metalloprotease	-
CHD36_RS24250	33133..33915	-	783	WP_000082172.1	site-specific integrase	-
CHD36_RS24255	33928..34463	-	536	Protein_41	cytoplasmic protein	-
CHD36_RS24260	34460..34750	-	291	WP_001266178.1	hypothetical protein	-
CHD36_RS24265	34752..35057	-	306	WP_001159874.1	type II toxin-antitoxin system toxin CcdB	-
CHD36_RS24270	35059..35277	-	219	WP_000813642.1	type II toxin-antitoxin system antitoxin CcdA	-
CHD36_RS24280	36023..36253	+	231	WP_001261289.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CHD36_RS24285	36250..36666	+	417	WP_000739001.1	type II toxin-antitoxin system VapC family toxin	Toxin
CHD36_RS24290	36713..40507	-	3795	WP_001144735.1	hypothetical protein	-
CHD36_RS24300	40855..41100	+	246	WP_000368360.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..97234	97234

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 17834.22 Da
• Isoelectric Point: 12.9398

>T107351 WP_000739001.1 NZ_CP030218:36250-36666 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 417 bp

>T107351 NZ_CP030218:36250-36666 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9887.42 Da
• Isoelectric Point: 12.6808

>AT107351 WP_001261289.1 NZ_CP030218:36023-36253 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 231 bp

>AT107351 NZ_CP030218:36023-36253 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A5U2RIY8