Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 34752..35277 Replicon plasmid pSA20075157.1
Accession NZ_CP030218
Organism Salmonella enterica strain SA20075157

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag CHD36_RS24265 Protein ID WP_001159874.1
Coordinates 34752..35057 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag CHD36_RS24270 Protein ID WP_000813642.1
Coordinates 35059..35277 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHD36_RS24810 31169..31321 + 153 WP_001838496.1 hypothetical protein -
CHD36_RS24245 31934..32629 - 696 WP_000389613.1 CPBP family intramembrane metalloprotease -
CHD36_RS24250 33133..33915 - 783 WP_000082172.1 site-specific integrase -
CHD36_RS24255 33928..34463 - 536 Protein_41 cytoplasmic protein -
CHD36_RS24260 34460..34750 - 291 WP_001266178.1 hypothetical protein -
CHD36_RS24265 34752..35057 - 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
CHD36_RS24270 35059..35277 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CHD36_RS24280 36023..36253 + 231 WP_001261289.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CHD36_RS24285 36250..36666 + 417 WP_000739001.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97234 97234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T107350 WP_001159874.1 NZ_CP030218:c35057-34752 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T107350 NZ_CP030218:c35057-34752 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT107350 WP_000813642.1 NZ_CP030218:c35277-35059 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT107350 NZ_CP030218:c35277-35059 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References