Detailed information of TA system TA107348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 13102..13627
• Replicon: plasmid pSA19992307.1
• Accession: NZ_CP030208
• Organism: Salmonella enterica strain SA19992307

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: CHC30_RS25015
• Protein ID: WP_001159863.1
• Coordinates: 13322..13627 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: CHC30_RS25010
• Protein ID: WP_000813641.1
• Coordinates: 13102..13320 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHC30_RS24965	8129..8842	+	714	WP_000801115.1	hypothetical protein	-
CHC30_RS24975	8967..9551	+	585	WP_001575501.1	hypothetical protein	-
CHC30_RS24980	9624..9836	+	213	WP_000063794.1	hypothetical protein	-
CHC30_RS25540	10097..10258	+	162	WP_001816720.1	hypothetical protein	-
CHC30_RS24985	10284..11132	+	849	WP_000175391.1	SdiA-regulated domain-containing protein	-
CHC30_RS25000	11702..12130	-	429	WP_000812999.1	type II toxin-antitoxin system VapC family toxin	-
CHC30_RS25005	12127..12357	-	231	WP_001261283.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
CHC30_RS25010	13102..13320	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CHC30_RS25015	13322..13627	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
CHC30_RS25020	13629..13919	+	291	WP_001266176.1	hypothetical protein	-
CHC30_RS25025	13916..14437	+	522	WP_000198608.1	hypothetical protein	-
CHC30_RS25030	14472..15254	+	783	WP_000082169.1	site-specific integrase	-
CHC30_RS25035	15263..15976	+	714	WP_000545756.1	EAL domain-containing protein	-
CHC30_RS25040	15980..16489	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
CHC30_RS25045	16483..16819	+	337	Protein_24	hypothetical protein	-
CHC30_RS25050	17031..17591	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
CHC30_RS25055	17658..18026	-	369	WP_001675946.1	helix-turn-helix domain-containing protein	-
CHC30_RS25060	18083..18508	+	426	WP_000064919.1	IS200/IS605 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74577	74577

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T107348 WP_001159863.1 NZ_CP030208:13322-13627 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T107348 NZ_CP030208:13322-13627 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT107348 WP_000813641.1 NZ_CP030208:13102-13320 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT107348 NZ_CP030208:13102-13320 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6