Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11702..12357 Replicon plasmid pSA19992307.1
Accession NZ_CP030208
Organism Salmonella enterica strain SA19992307

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag CHC30_RS25000 Protein ID WP_000812999.1
Coordinates 11702..12130 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag CHC30_RS25005 Protein ID WP_001261283.1
Coordinates 12127..12357 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHC30_RS24955 7103..7867 + 765 WP_000827659.1 K88 minor fimbrial subunit faeI -
CHC30_RS24960 7854..8129 + 276 WP_001020576.1 hypothetical protein -
CHC30_RS24965 8129..8842 + 714 WP_000801115.1 hypothetical protein -
CHC30_RS24975 8967..9551 + 585 WP_001575501.1 hypothetical protein -
CHC30_RS24980 9624..9836 + 213 WP_000063794.1 hypothetical protein -
CHC30_RS25540 10097..10258 + 162 WP_001816720.1 hypothetical protein -
CHC30_RS24985 10284..11132 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
CHC30_RS25000 11702..12130 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
CHC30_RS25005 12127..12357 - 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CHC30_RS25010 13102..13320 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
CHC30_RS25015 13322..13627 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
CHC30_RS25020 13629..13919 + 291 WP_001266176.1 hypothetical protein -
CHC30_RS25025 13916..14437 + 522 WP_000198608.1 hypothetical protein -
CHC30_RS25030 14472..15254 + 783 WP_000082169.1 site-specific integrase -
CHC30_RS25035 15263..15976 + 714 WP_000545756.1 EAL domain-containing protein -
CHC30_RS25040 15980..16489 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
CHC30_RS25045 16483..16819 + 337 Protein_24 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74577 74577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 21064.27 Da        Isoelectric Point: 5.5500

>T107347 WP_000812999.1 NZ_CP030208:c12130-11702 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 429 bp

>T107347 NZ_CP030208:c12130-11702 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT107347 WP_001261283.1 NZ_CP030208:c12357-12127 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT107347 NZ_CP030208:c12357-12127 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References