Detailed information of TA system TA107343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 23496..24021
• Replicon: plasmid pSA20083530.1
• Accession: NZ_CP030204
• Organism: Salmonella enterica strain SA20083530

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: CHD70_RS26970
• Protein ID: WP_001159863.1
• Coordinates: 23716..24021 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: I3W3D6
• Locus tag: CHD70_RS26965
• Protein ID: WP_015062698.1
• Coordinates: 23496..23714 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHD70_RS28405	19225..19425	+	201	Protein_19	IS3 family transposase	-
CHD70_RS26930	19716..20224	-	509	Protein_20	transposase	-
CHD70_RS26935	20230..20346	+	117	Protein_21	IS630 family transposase	-
CHD70_RS26940	20391..20858	-	468	WP_114047595.1	helix-turn-helix domain-containing protein	-
CHD70_RS26945	21136..21744	+	609	Protein_23	IS6 family transposase	-
CHD70_RS26955	21882..22526	-	645	WP_114047596.1	hypothetical protein	-
CHD70_RS26960	22523..22783	-	261	WP_114047597.1	hypothetical protein	-
CHD70_RS26965	23496..23714	+	219	WP_015062698.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CHD70_RS26970	23716..24021	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
CHD70_RS26975	24023..24349	+	327	WP_114047598.1	cytoplasmic protein	-
CHD70_RS26980	24339..25130	+	792	WP_114047599.1	site-specific integrase	-
CHD70_RS26985	25364..26227	-	864	WP_114047600.1	RepB family plasmid replication initiator protein	-
CHD70_RS26990	26755..27396	+	642	WP_114047601.1	ParA family protein	-
CHD70_RS26995	27465..27803	+	339	WP_015062732.1	hypothetical protein	-
CHD70_RS27000	27952..28224	-	273	Protein_33	DUF4113 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..138648	138648

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-45)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T107343 WP_001159863.1 NZ_CP030204:23716-24021 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T107343 NZ_CP030204:23716-24021 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT107343 WP_015062698.1 NZ_CP030204:23496-23714 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT107343 NZ_CP030204:23496-23714 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: I3W3D6