Detailed information of TA system TA107337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-Phd
• Location: 65666..66267
• Replicon: plasmid pSA20030575.2
• Accession: NZ_CP030183
• Organism: Salmonella enterica strain SA20030575

Toxin (Protein)

• Gene name: doc
• Uniprot ID: U9YA20
• Locus tag: CHC58_RS26025
• Protein ID: WP_001216045.1
• Coordinates: 65666..66046 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: U9YQH9
• Locus tag: CHC58_RS26030
• Protein ID: WP_001190712.1
• Coordinates: 66046..66267 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHC58_RS26000	61106..62590	-	1485	WP_000124150.1	terminase	-
CHC58_RS26005	62590..63783	-	1194	WP_114071658.1	terminase	-
CHC58_RS26010	63870..64322	-	453	WP_001312282.1	late promoter-activating protein (Gp10)	-
CHC58_RS26015	64411..65454	-	1044	WP_114071659.1	DUF968 domain-containing protein	-
CHC58_RS26020	65482..65661	-	180	WP_001372234.1	hypothetical protein	-
CHC58_RS26025	65666..66046	-	381	WP_001216045.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
CHC58_RS26030	66046..66267	-	222	WP_001190712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CHC58_RS26035	66340..66729	-	390	WP_000506724.1	DNA repair protein	-
CHC58_RS26040	66853..67104	-	252	WP_001283837.1	DNA polymerase III subunit theta	-
CHC58_RS26045	67278..67487	+	210	WP_001344848.1	hypothetical protein	-
CHC58_RS26050	67472..67756	-	285	WP_001142394.1	hypothetical protein	-
CHC58_RS26055	67740..68390	-	651	WP_000057451.1	hypothetical protein	-
CHC58_RS26060	68372..68746	-	375	WP_114071660.1	hypothetical protein	-
CHC58_RS26065	68753..69046	-	294	WP_000269002.1	hypothetical protein	-
CHC58_RS26070	69225..69458	-	234	WP_000517421.1	hypothetical protein	-
CHC58_RS26080	69544..69804	-	261	WP_114071661.1	eaa protein	-
CHC58_RS26085	69801..71036	-	1236	WP_114071670.1	DUF551 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94179	94179

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 18709.44 Da
• Isoelectric Point: 5.5500

>T107337 WP_001216045.1 NZ_CP030183:c66046-65666 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 381 bp

>T107337 NZ_CP030183:c66046-65666 [Salmonella enterica]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 10909.08 Da
• Isoelectric Point: 5.5500

>AT107337 WP_001190712.1 NZ_CP030183:c66267-66046 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 222 bp

>AT107337 NZ_CP030183:c66267-66046 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A829CLP7

Antitoxin

• AlphaFold DB: A0A829CJB6