Detailed information of TA system TA107333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 62097..62752
• Replicon: plasmid pIncFII.1
• Accession: NZ_CP030176
• Organism: Salmonella enterica subsp. enterica serovar Milwaukee str. SA19950795

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: LFZ28_RS25060
• Protein ID: WP_058108470.1
• Coordinates: 62097..62525 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: LFZ28_RS25065
• Protein ID: WP_058108471.1
• Coordinates: 62522..62752 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ28_RS26445	58104..58400	+	297	WP_073998961.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LFZ28_RS25035	58454..59473	-	1020	WP_058108468.1	hypothetical protein	-
LFZ28_RS25045	60383..61114	-	732	WP_058108469.1	type III secretion system effector phosphothreonine lyase	-
LFZ28_RS25050	61189..61437	-	249	Protein_59	hypothetical protein	-
LFZ28_RS25060	62097..62525	-	429	WP_058108470.1	type II toxin-antitoxin system VapC family toxin	Toxin
LFZ28_RS25065	62522..62752	-	231	WP_058108471.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LFZ28_RS25075	63298..64260	+	963	WP_058108472.1	hypothetical protein	-
LFZ28_RS25080	64261..64587	+	327	WP_058108473.1	hypothetical protein	-
LFZ28_RS25085	64577..65365	+	789	WP_058108474.1	site-specific integrase	-
LFZ28_RS25090	65869..66564	+	696	WP_000389613.1	CPBP family intramembrane metalloprotease	-
LFZ28_RS26560	67179..67331	-	153	WP_001838496.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..148530	148530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 21064.27 Da
• Isoelectric Point: 5.5500

>T107333 WP_058108470.1 NZ_CP030176:c62525-62097 [Salmonella enterica subsp. enterica serovar Milwaukee str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 429 bp

>T107333 NZ_CP030176:c62525-62097 [Salmonella enterica subsp. enterica serovar Milwaukee str.]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT107333 WP_058108471.1 NZ_CP030176:c62752-62522 [Salmonella enterica subsp. enterica serovar Milwaukee str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT107333 NZ_CP030176:c62752-62522 [Salmonella enterica subsp. enterica serovar Milwaukee str.]
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