Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1222495..1223114 Replicon chromosome
Accession NZ_CP030174
Organism Klebsiella pneumoniae subsp. pneumoniae strain 11219

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DQB71_RS06060 Protein ID WP_002892050.1
Coordinates 1222495..1222713 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DQB71_RS06065 Protein ID WP_002892066.1
Coordinates 1222740..1223114 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQB71_RS06030 1218542..1218805 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
DQB71_RS06035 1218805..1218945 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DQB71_RS06040 1218942..1219640 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
DQB71_RS06045 1219741..1221192 + 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
DQB71_RS06050 1221167..1221637 - 471 WP_002892026.1 YlaC family protein -
DQB71_RS27590 1221658..1221798 + 141 WP_004147370.1 hypothetical protein -
DQB71_RS06055 1221770..1222336 - 567 WP_002892030.1 maltose O-acetyltransferase -
DQB71_RS06060 1222495..1222713 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DQB71_RS06065 1222740..1223114 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DQB71_RS06070 1223600..1226746 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
DQB71_RS06075 1226769..1227962 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T107317 WP_002892050.1 NZ_CP030174:c1222713-1222495 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T107317 NZ_CP030174:c1222713-1222495 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATTCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT107317 WP_002892066.1 NZ_CP030174:c1223114-1222740 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT107317 NZ_CP030174:c1223114-1222740 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References