Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 311259..311890 Replicon chromosome
Accession NZ_CP030173
Organism Klebsiella variicola strain 13450

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DQB70_RS01495 Protein ID WP_022066423.1
Coordinates 311259..311534 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DQB70_RS01500 Protein ID WP_022066422.1
Coordinates 311531..311890 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQB70_RS01475 306495..306830 + 336 WP_002921203.1 universal stress protein UspB -
DQB70_RS01480 306890..308386 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
DQB70_RS01485 308616..309809 + 1194 WP_012967106.1 NAD(P)/FAD-dependent oxidoreductase -
DQB70_RS01490 309849..310862 - 1014 WP_022066424.1 magnesium transporter -
DQB70_RS01495 311259..311534 + 276 WP_022066423.1 type II toxin-antitoxin system HicA family toxin Toxin
DQB70_RS01500 311531..311890 + 360 WP_022066422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQB70_RS01505 311918..312319 - 402 WP_022066421.1 nickel-responsive transcriptional regulator NikR -
DQB70_RS01510 312307..313098 - 792 WP_012540373.1 nickel import ATP-binding protein NikE -
DQB70_RS01515 313095..313859 - 765 WP_048272087.1 nickel import ATP-binding protein NikD -
DQB70_RS01520 313859..314692 - 834 WP_048272086.1 nickel ABC transporter permease subunit NikC -
DQB70_RS01525 314689..315633 - 945 WP_022066418.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10267.85 Da        Isoelectric Point: 10.3165

>T107293 WP_022066423.1 NZ_CP030173:311259-311534 [Klebsiella variicola]
MEQQVLSLRNKQRHTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T107293 NZ_CP030173:311259-311534 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGTTGGAGCAACTGTTTAAAACCCCTGTCCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATCAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13294.99 Da        Isoelectric Point: 4.4605

>AT107293 WP_022066422.1 NZ_CP030173:311531-311890 [Klebsiella variicola]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT107293 NZ_CP030173:311531-311890 [Klebsiella variicola]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGGCAACCCGCCGTTATCAACTACGTGCCTGAGCTCAATGC
ATTCCGTGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGCTGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCGGAGGAACAGGTTTCCGTAAACACCTG
GATCCTCGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References