Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4657452..4657968 Replicon chromosome
Accession NZ_CP030172
Organism Klebsiella pneumoniae subsp. pneumoniae strain 12208

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag DQB68_RS23120 Protein ID WP_002886902.1
Coordinates 4657452..4657736 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DQB68_RS23125 Protein ID WP_002886901.1
Coordinates 4657726..4657968 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQB68_RS23100 4652869..4653177 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
DQB68_RS26855 4653262..4653435 + 174 WP_032410138.1 hypothetical protein -
DQB68_RS23105 4653438..4654181 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
DQB68_RS23110 4654538..4656676 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
DQB68_RS23115 4656984..4657448 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DQB68_RS23120 4657452..4657736 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQB68_RS23125 4657726..4657968 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQB68_RS23130 4658046..4659956 - 1911 WP_004152270.1 BglG family transcription antiterminator -
DQB68_RS23135 4659979..4661133 - 1155 WP_002886900.1 lactonase family protein -
DQB68_RS23140 4661200..4661940 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T107290 WP_002886902.1 NZ_CP030172:c4657736-4657452 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T107290 NZ_CP030172:c4657736-4657452 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT107290 WP_002886901.1 NZ_CP030172:c4657968-4657726 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT107290 NZ_CP030172:c4657968-4657726 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References