Detailed information of TA system TA107289

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4568623..4569326
• Replicon: chromosome
• Accession: NZ_CP030172
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain 12208

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: DQB68_RS22715
• Protein ID: WP_032728834.1
• Coordinates: 4568623..4568964 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: DQB68_RS22720
• Protein ID: WP_062729743.1
• Coordinates: 4568985..4569326 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQB68_RS22695	4564108..4565595	+	1488	WP_063417176.1	hypothetical protein	-
DQB68_RS22710	4567357..4568364	-	1008	WP_039268719.1	restriction endonuclease	-
DQB68_RS22715	4568623..4568964	-	342	WP_032728834.1	TA system toxin CbtA family protein	Toxin
DQB68_RS22720	4568985..4569326	-	342	WP_062729743.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DQB68_RS22725	4569337..4569876	-	540	WP_062729744.1	DNA repair protein RadC	-
DQB68_RS22730	4569889..4570332	-	444	WP_049594271.1	antirestriction protein	-
DQB68_RS22735	4570363..4571184	-	822	WP_062729745.1	DUF945 domain-containing protein	-
DQB68_RS22740	4571283..4571513	-	231	WP_062729746.1	DUF905 domain-containing protein	-
DQB68_RS22745	4571585..4572034	-	450	WP_062729747.1	hypothetical protein	-
DQB68_RS22750	4572031..4572483	-	453	WP_062729748.1	hypothetical protein	-
DQB68_RS22755	4572521..4573090	-	570	WP_063417175.1	hypothetical protein	-
DQB68_RS22760	4573090..4573794	-	705	WP_062729750.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4555110..4599159	44049

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12777.71 Da
• Isoelectric Point: 7.1648

>T107289 WP_032728834.1 NZ_CP030172:c4568964-4568623 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Nucleotide

• Length: 342 bp

>T107289 NZ_CP030172:c4568964-4568623 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTATCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATAACTTTGGCCGATGCCGTTAACTTTTTGGTAGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGATTC
AACTGGCAGGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12747.39 Da
• Isoelectric Point: 6.6214

>AT107289 WP_062729743.1 NZ_CP030172:c4569326-4568985 [Klebsiella pneumoniae subsp. pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCFTLYHNGFSCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 342 bp

>AT107289 NZ_CP030172:c4569326-4568985 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTACACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTTTCACCCTGTACCACAATGGTTTCTCCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACATCGC
CGTTTACCCCACTCAACGTTAA