Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842368..843025 Replicon chromosome
Accession NZ_CP030171
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain A708

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag DP204_RS04330 Protein ID WP_023290968.1
Coordinates 842615..843025 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DP204_RS04325 Protein ID WP_002916312.1
Coordinates 842368..842634 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP204_RS04300 837518..838951 - 1434 WP_112201234.1 6-phospho-beta-glucosidase -
DP204_RS04305 839070..839798 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
DP204_RS04310 839849..840160 + 312 WP_080820267.1 N(4)-acetylcytidine aminohydrolase -
DP204_RS04315 840324..840983 + 660 WP_008806429.1 hemolysin III family protein -
DP204_RS04320 841139..842122 - 984 WP_112201235.1 tRNA-modifying protein YgfZ -
DP204_RS04325 842368..842634 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DP204_RS04330 842615..843025 + 411 WP_023290968.1 protein YgfX Toxin
DP204_RS04335 843032..843553 - 522 WP_004205324.1 flavodoxin FldB -
DP204_RS04340 843654..844550 + 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
DP204_RS04345 844573..845286 + 714 WP_049014195.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DP204_RS04350 845292..847025 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T107263 WP_023290968.1 NZ_CP030171:842615-843025 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T107263 NZ_CP030171:842615-843025 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT107263 WP_002916312.1 NZ_CP030171:842368-842634 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT107263 NZ_CP030171:842368-842634 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References