Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 84292..84962 Replicon plasmid unnamed
Accession NZ_CP030165
Organism Xanthomonas citri pv. punicae strain LMG7439

Toxin (Protein)


Gene name vapC Uniprot ID A0A6M2XLD2
Locus tag XapA_RS23600 Protein ID WP_005934647.1
Coordinates 84292..84711 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6M2XXM0
Locus tag XapA_RS23605 Protein ID WP_033480715.1
Coordinates 84708..84962 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XapA_RS23580 79392..79778 + 387 Protein_86 putative toxin-antitoxin system toxin component, PIN family -
XapA_RS23585 79812..82781 + 2970 Protein_87 Tn3 family transposase -
XapA_RS23590 82786..83494 + 709 Protein_88 UPF0149 family protein -
XapA_RS23595 83964..84164 + 201 WP_005934645.1 hypothetical protein -
XapA_RS23600 84292..84711 - 420 WP_005934647.1 type II toxin-antitoxin system VapC family toxin Toxin
XapA_RS23605 84708..84962 - 255 WP_033480715.1 Arc family DNA-binding protein Antitoxin
XapA_RS23610 85296..85541 - 246 WP_157383756.1 hypothetical protein -
XapA_RS23620 86121..87197 - 1077 WP_174854939.1 avirulence protein -
XapA_RS23625 87331..88384 - 1054 Protein_94 DNA-binding protein -
XapA_RS23630 88569..89012 + 444 Protein_95 Tn3 family resolvase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..157583 157583
- inside IScluster/Tn - - 78027..89018 10991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14897.11 Da        Isoelectric Point: 5.1890

>T107261 WP_005934647.1 NZ_CP030165:c84711-84292 [Xanthomonas citri pv. punicae]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T107261 NZ_CP030165:c84711-84292 [Xanthomonas citri pv. punicae]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
ACAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTGGCCGAGCTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAGAAAGGCTTGGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGGTTCCCAACACCCGACGGATATATCGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTTGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9522.89 Da        Isoelectric Point: 6.4771

>AT107261 WP_033480715.1 NZ_CP030165:c84962-84708 [Xanthomonas citri pv. punicae]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNEDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT107261 NZ_CP030165:c84962-84708 [Xanthomonas citri pv. punicae]
ATGGCAATCCTGACAGTGCGGAATGTGCCGGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTGCGCGAGATTCTGGAAAGTGCAGTGAAGTCGGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCGCGTAGGGCTGACAAACGAAGACTTCGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M2XLD2

Antitoxin

Source ID Structure
AlphaFold DB A0A6M2XXM0

References