Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 109026..109693 Replicon chromosome
Accession NZ_CP030164
Organism Xanthomonas citri pv. punicae strain LMG7439

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag XapA_RS00510 Protein ID WP_005916679.1
Coordinates 109026..109442 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag XapA_RS00515 Protein ID WP_005916676.1
Coordinates 109439..109693 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XapA_RS24070 104649..104870 - 222 WP_172637392.1 hypothetical protein -
XapA_RS00485 104761..105671 + 911 Protein_90 LysR family transcriptional regulator -
XapA_RS00490 105871..106581 + 711 WP_050550563.1 hypothetical protein -
XapA_RS00495 106780..107427 - 648 WP_033480173.1 NAD(P)H-dependent oxidoreductase -
XapA_RS00500 107490..108452 - 963 WP_160964030.1 IS1595 family transposase -
XapA_RS00505 108625..108897 + 273 WP_174854856.1 hypothetical protein -
XapA_RS00510 109026..109442 - 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
XapA_RS00515 109439..109693 - 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
XapA_RS00520 109834..110940 - 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
XapA_RS00525 110927..111133 - 207 WP_003489327.1 hypothetical protein -
XapA_RS00530 111372..111899 + 528 WP_005916668.1 hypothetical protein -
XapA_RS00535 111925..113190 - 1266 WP_005931303.1 cardiolipin synthase B -
XapA_RS00540 113375..113584 - 210 WP_108350128.1 RNA 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 107490..108452 962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T107257 WP_005916679.1 NZ_CP030164:c109442-109026 [Xanthomonas citri pv. punicae]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T107257 NZ_CP030164:c109442-109026 [Xanthomonas citri pv. punicae]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTGGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT107257 WP_005916676.1 NZ_CP030164:c109693-109439 [Xanthomonas citri pv. punicae]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT107257 NZ_CP030164:c109693-109439 [Xanthomonas citri pv. punicae]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References