Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 25666..26167 | Replicon | plasmid pJSMCR1_4 |
| Accession | NZ_CP030156 | ||
| Organism | Escherichia coli strain JSMCR1 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | JSMCR1_RS25600 | Protein ID | WP_000702247.1 |
| Coordinates | 25666..25926 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | JSMCR1_RS25605 | Protein ID | WP_001132407.1 |
| Coordinates | 25916..26167 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSMCR1_RS25550 (JSMCR1_p594) | 21204..21356 | + | 153 | Protein_32 | FlmC family protein | - |
| JSMCR1_RS25555 | 21304..21423 | + | 120 | WP_228932012.1 | Hok/Gef family protein | - |
| JSMCR1_RS25560 (JSMCR1_p595) | 21573..22169 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| JSMCR1_RS25565 (JSMCR1_p596) | 22187..22471 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| JSMCR1_RS25570 (JSMCR1_p597) | 22545..23210 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| JSMCR1_RS25575 (JSMCR1_p599) | 23808..24137 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| JSMCR1_RS25580 (JSMCR1_p600) | 24246..24392 | - | 147 | WP_001356709.1 | hypothetical protein | - |
| JSMCR1_RS25585 (JSMCR1_p602) | 24719..25042 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| JSMCR1_RS25590 (JSMCR1_p603) | 25084..25293 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| JSMCR1_RS25595 (JSMCR1_p604) | 25390..25614 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| JSMCR1_RS25600 (JSMCR1_p605) | 25666..25926 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| JSMCR1_RS25605 (JSMCR1_p606) | 25916..26167 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| JSMCR1_RS25610 (JSMCR1_p608) | 26717..26995 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| JSMCR1_RS25615 (JSMCR1_p610) | 27415..27681 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JSMCR1_RS25620 (JSMCR1_p611) | 27788..28231 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| JSMCR1_RS25625 (JSMCR1_p613) | 28528..28710 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| JSMCR1_RS25630 (JSMCR1_p614) | 28735..29172 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JSMCR1_RS25635 (JSMCR1_p615) | 29303..29629 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| JSMCR1_RS25640 (JSMCR1_p616) | 29649..30356 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| JSMCR1_RS25645 (JSMCR1_p617) | 30358..31110 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61828 | 61828 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T107253 WP_000702247.1 NZ_CP030156:25666-25926 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T107253 NZ_CP030156:25666-25926 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT107253 WP_001132407.1 NZ_CP030156:25916-26167 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT107253 NZ_CP030156:25916-26167 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|