Detailed information of TA system TA107246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 119021..119556
• Replicon: plasmid pJSMCR1_2
• Accession: NZ_CP030154
• Organism: Escherichia coli strain JSMCR1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JSMCR1_RS24725
• Protein ID: WP_032206513.1
• Coordinates: 119269..119556 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JSMCR1_RS24720
• Protein ID: WP_032206515.1
• Coordinates: 119021..119272 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSMCR1_RS24715 (JSMCR1_p378)	114470..118438	-	3969	Protein_121	helicase-related protein	-
JSMCR1_RS24720 (JSMCR1_p380)	119021..119272	+	252	WP_032206515.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JSMCR1_RS24725 (JSMCR1_p381)	119269..119556	+	288	WP_032206513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JSMCR1_RS24735 (JSMCR1_p385)	120778..124275	-	3498	WP_001038839.1	autotransporter outer membrane beta-barrel domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	tet(A) / qnrS1 / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / dfrA14 / floR	-	1..134064	134064

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11130.20 Da
• Isoelectric Point: 10.5833

>T107246 WP_032206513.1 NZ_CP030154:119269-119556 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQIIDDMLIIAVVAVGK
RERSNVYHLASERMK

Nucleotide

• Length: 288 bp

>T107246 NZ_CP030154:119269-119556 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGATTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9161.35 Da
• Isoelectric Point: 4.0927

>AT107246 WP_032206515.1 NZ_CP030154:119021-119272 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQSLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT107246 NZ_CP030154:119021-119272 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGTCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA