107207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2227423..2228048 Replicon chromosome
Accession NZ_CP030138
Organism Staphylococcus aureus strain M48

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag C2G36_RS11930 Protein ID WP_001179607.1
Coordinates 2227423..2227818 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag C2G36_RS11935 Protein ID WP_000258939.1
Coordinates 2227818..2228048 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2G36_RS11890 2222978..2223418 - 441 Protein_2200 GNAT family N-acetyltransferase -
C2G36_RS11895 2223393..2223644 - 252 WP_002505594.1 hypothetical protein -
C2G36_RS11900 2223641..2224276 - 636 Protein_2202 aminoglycoside 6-adenylyltransferase -
C2G36_RS11905 2224491..2225213 - 723 WP_001043218.1 hypothetical protein -
C2G36_RS11910 2225322..2226122 - 801 WP_000686449.1 metallophosphoesterase -
C2G36_RS11915 2226126..2226620 - 495 WP_000280790.1 hypothetical protein -
C2G36_RS11920 2226677..2226946 - 270 WP_000755772.1 hypothetical protein -
C2G36_RS11925 2226930..2227121 - 192 WP_032605691.1 hypothetical protein -
C2G36_RS11930 2227423..2227818 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
C2G36_RS11935 2227818..2228048 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
C2G36_RS11940 2228224..2228745 - 522 WP_000639078.1 metallophosphoesterase -
C2G36_RS11945 2228745..2229395 - 651 WP_000411528.1 hypothetical protein -
C2G36_RS11950 2229395..2229712 - 318 WP_001807410.1 hypothetical protein -
C2G36_RS11955 2229705..2230430 - 726 WP_000197304.1 metallophosphoesterase -
C2G36_RS11960 2230430..2230651 - 222 WP_000829423.1 hypothetical protein -
C2G36_RS16300 2230671..2230847 - 177 WP_000063384.1 hypothetical protein -
C2G36_RS11965 2230840..2231382 - 543 WP_000858632.1 hypothetical protein -
C2G36_RS11970 2231397..2231669 - 273 WP_000691100.1 hypothetical protein -
C2G36_RS11975 2231695..2231850 - 156 WP_000792995.1 transcriptional regulator -
C2G36_RS16305 2231964..2232131 - 168 WP_000312832.1 hypothetical protein -
C2G36_RS11980 2232147..2232332 - 186 WP_001187008.1 hypothetical protein -
C2G36_RS11985 2232317..2232496 - 180 WP_000401832.1 hypothetical protein -
C2G36_RS11990 2232510..2232992 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2188499..2320181 131682


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T107207 WP_001179607.1 NZ_CP030138:c2227818-2227423 [Staphylococcus aureus]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T107207 NZ_CP030138:c2227818-2227423 [Staphylococcus aureus]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT107207 WP_000258939.1 NZ_CP030138:c2228048-2227818 [Staphylococcus aureus]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT107207 NZ_CP030138:c2228048-2227818 [Staphylococcus aureus]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References