Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 2047228..2048019 | Replicon | chromosome |
| Accession | NZ_CP030138 | ||
| Organism | Staphylococcus aureus strain M48 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | C2G36_RS10745 | Protein ID | WP_000525003.1 |
| Coordinates | 2047555..2048019 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | C2G36_RS10740 | Protein ID | WP_000333630.1 |
| Coordinates | 2047228..2047542 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2G36_RS10690 | 2043477..2043740 | - | 264 | WP_001205732.1 | hypothetical protein | - |
| C2G36_RS10695 | 2043749..2044009 | - | 261 | WP_031825655.1 | DUF1108 family protein | - |
| C2G36_RS10700 | 2044014..2044316 | - | 303 | WP_044131919.1 | DUF2482 family protein | - |
| C2G36_RS10705 | 2044410..2044571 | - | 162 | WP_000048130.1 | DUF1270 family protein | - |
| C2G36_RS10710 | 2044564..2044785 | - | 222 | WP_000594790.1 | hypothetical protein | - |
| C2G36_RS10715 | 2044856..2045086 | + | 231 | WP_000395455.1 | hypothetical protein | - |
| C2G36_RS10720 | 2045262..2046005 | - | 744 | WP_001148594.1 | phage antirepressor KilAC domain-containing protein | - |
| C2G36_RS10725 | 2046065..2046547 | + | 483 | WP_000394410.1 | hypothetical protein | - |
| C2G36_RS10730 | 2046648..2046827 | - | 180 | WP_000438352.1 | hypothetical protein | - |
| C2G36_RS10735 | 2046846..2047076 | - | 231 | WP_103263741.1 | helix-turn-helix domain-containing protein | - |
| C2G36_RS10740 | 2047228..2047542 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| C2G36_RS10745 | 2047555..2048019 | + | 465 | WP_000525003.1 | hypothetical protein | Toxin |
| C2G36_RS10750 | 2048051..2048980 | + | 930 | WP_129367418.1 | hypothetical protein | - |
| C2G36_RS10755 | 2048960..2049139 | - | 180 | WP_000337827.1 | hypothetical protein | - |
| C2G36_RS10760 | 2049252..2050298 | + | 1047 | WP_001145722.1 | site-specific integrase | - |
| C2G36_RS10765 | 2050343..2051488 | + | 1146 | WP_001245441.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| C2G36_RS10770 | 2051748..2052278 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2005895..2050298 | 44403 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18156.52 Da Isoelectric Point: 4.7927
>T107202 WP_000525003.1 NZ_CP030138:2047555-2048019 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID
Download Length: 465 bp
>T107202 NZ_CP030138:2047555-2048019 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATCACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCACATTGATTAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATCACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCACATTGATTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT107202 WP_000333630.1 NZ_CP030138:2047228-2047542 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT107202 NZ_CP030138:2047228-2047542 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|