Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 924002..924507 Replicon chromosome
Accession NZ_CP030138
Organism Staphylococcus aureus strain M48

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag C2G36_RS04820 Protein ID WP_001103946.1
Coordinates 924214..924507 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag C2G36_RS04815 Protein ID WP_001058492.1
Coordinates 924002..924211 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2G36_RS04780 919519..920739 - 1221 WP_000264182.1 site-specific integrase -
C2G36_RS04785 920827..921555 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
C2G36_RS04790 921579..922307 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
C2G36_RS04795 922482..923216 - 735 WP_000142630.1 helix-turn-helix domain-containing protein -
C2G36_RS04800 923366..923578 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
C2G36_RS04805 923579..923851 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
C2G36_RS04810 923863..924009 + 147 WP_000784885.1 hypothetical protein -
C2G36_RS04815 924002..924211 + 210 WP_001058492.1 hypothetical protein Antitoxin
C2G36_RS04820 924214..924507 + 294 WP_001103946.1 DUF1474 family protein Toxin
C2G36_RS04825 924595..925464 + 870 WP_001002691.1 primase alpha helix C-terminal domain-containing protein -
C2G36_RS04830 925481..926938 + 1458 WP_000432707.1 virulence-associated E family protein -
C2G36_RS04835 927240..927602 + 363 WP_001039172.1 hypothetical protein -
C2G36_RS04840 927604..927888 + 285 WP_000998180.1 hypothetical protein -
C2G36_RS04845 927885..928526 + 642 WP_001019783.1 hypothetical protein -
C2G36_RS04850 928975..929316 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 901568..931630 30062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T107198 WP_001103946.1 NZ_CP030138:924214-924507 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T107198 NZ_CP030138:924214-924507 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT107198 WP_001058492.1 NZ_CP030138:924002-924211 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT107198 NZ_CP030138:924002-924211 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References