Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 906885..907362 Replicon chromosome
Accession NZ_CP030138
Organism Staphylococcus aureus strain M48

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag C2G36_RS04675 Protein ID WP_000052078.1
Coordinates 906885..907073 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C2G36_RS04680 Protein ID WP_001059690.1
Coordinates 907102..907362 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2G36_RS04645 902925..903395 + 471 WP_000824472.1 hypothetical protein -
C2G36_RS04650 903736..904422 + 687 WP_001548082.1 thermonuclease family protein -
C2G36_RS04655 904779..904979 + 201 WP_001059082.1 cold-shock protein -
C2G36_RS04660 905476..905694 - 219 WP_000005886.1 hypothetical protein -
C2G36_RS04665 905756..906040 - 285 WP_001004395.1 hypothetical protein -
C2G36_RS04670 906128..906697 - 570 WP_001106654.1 hypothetical protein -
C2G36_RS04675 906885..907073 - 189 WP_000052078.1 hypothetical protein Toxin
C2G36_RS04680 907102..907362 - 261 WP_001059690.1 hypothetical protein Antitoxin
C2G36_RS04685 907703..907906 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C2G36_RS04690 907903..908139 - 237 WP_000368687.1 hypothetical protein -
C2G36_RS04695 908364..908945 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
C2G36_RS04700 909018..909635 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
C2G36_RS04705 909790..910284 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
C2G36_RS04710 910683..911105 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
C2G36_RS04715 911253..911969 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 901568..931630 30062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T107197 WP_000052078.1 NZ_CP030138:c907073-906885 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T107197 NZ_CP030138:c907073-906885 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT107197 WP_001059690.1 NZ_CP030138:c907362-907102 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT107197 NZ_CP030138:c907362-907102 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References