107196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1910462..1910939 Replicon chromosome
Accession NZ_CP030137
Organism Staphylococcus aureus strain M51

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag C2G35_RS10145 Protein ID WP_000052078.1
Coordinates 1910751..1910939 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C2G35_RS10140 Protein ID WP_001059690.1
Coordinates 1910462..1910722 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2G35_RS10105 1905855..1906571 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
C2G35_RS10110 1906719..1907141 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
C2G35_RS10115 1907540..1908034 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
C2G35_RS10120 1908189..1908806 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
C2G35_RS10125 1908879..1909460 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
C2G35_RS10130 1909685..1909921 + 237 WP_000368687.1 hypothetical protein -
C2G35_RS10135 1909918..1910121 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C2G35_RS10140 1910462..1910722 + 261 WP_001059690.1 hypothetical protein Antitoxin
C2G35_RS10145 1910751..1910939 + 189 WP_000052078.1 hypothetical protein Toxin
C2G35_RS10150 1911127..1911696 + 570 WP_001106654.1 hypothetical protein -
C2G35_RS10155 1911784..1912068 + 285 WP_001004395.1 hypothetical protein -
C2G35_RS10160 1912130..1912348 + 219 WP_000005886.1 hypothetical protein -
C2G35_RS10165 1912844..1913044 - 201 WP_001059082.1 cold-shock protein -
C2G35_RS10170 1913401..1914087 - 687 WP_001548082.1 thermonuclease family protein -
C2G35_RS10175 1914428..1914898 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(10-56)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T107196 WP_000052078.1 NZ_CP030137:1910751-1910939 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T107196 NZ_CP030137:1910751-1910939 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT107196 WP_001059690.1 NZ_CP030137:1910462-1910722 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT107196 NZ_CP030137:1910462-1910722 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References