Detailed information of TA system TA107189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 662795..663324
• Replicon: chromosome
• Accession: NZ_CP030137
• Organism: Staphylococcus aureus strain M51

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: C2G35_RS03520
• Protein ID: WP_000621175.1
• Coordinates: 662962..663324 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: C2G35_RS03515
• Protein ID: WP_000948331.1
• Coordinates: 662795..662965 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2G35_RS03485	657832..658392	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
C2G35_RS03490	658600..659079	+	480	WP_001287088.1	hypothetical protein	-
C2G35_RS03495	659072..660655	+	1584	WP_001294626.1	PH domain-containing protein	-
C2G35_RS03500	660642..661133	+	492	WP_001205910.1	PH domain-containing protein	-
C2G35_RS03505	661137..661496	+	360	WP_000581200.1	holo-ACP synthase	-
C2G35_RS03510	661562..662710	+	1149	WP_001281145.1	alanine racemase	-
C2G35_RS03515	662795..662965	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
C2G35_RS03520	662962..663324	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
C2G35_RS03530	663674..664675	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
C2G35_RS03535	664794..665120	+	327	WP_001052491.1	anti-sigma factor antagonist	-
C2G35_RS03540	665122..665601	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
C2G35_RS03545	665576..666346	+	771	WP_001041103.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T107189 WP_000621175.1 NZ_CP030137:662962-663324 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T107189 NZ_CP030137:662962-663324 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT107189 WP_000948331.1 NZ_CP030137:662795-662965 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT107189 NZ_CP030137:662795-662965 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1