107179

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1936514..1936991 Replicon chromosome
Accession NZ_CP030136
Organism Staphylococcus aureus strain S57

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CHN55_RS10255 Protein ID WP_000052076.1
Coordinates 1936803..1936991 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CHN55_RS10250 Protein ID WP_001059690.1
Coordinates 1936514..1936774 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHN55_RS10215 1931906..1932622 - 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -
CHN55_RS10220 1932770..1933192 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CHN55_RS10225 1933591..1934085 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CHN55_RS10230 1934241..1934858 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
CHN55_RS10235 1934931..1935512 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
CHN55_RS10240 1935737..1935973 + 237 WP_000368687.1 hypothetical protein -
CHN55_RS10245 1935970..1936173 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CHN55_RS10250 1936514..1936774 + 261 WP_001059690.1 hypothetical protein Antitoxin
CHN55_RS10255 1936803..1936991 + 189 WP_000052076.1 hypothetical protein Toxin
CHN55_RS10260 1937179..1937748 + 570 WP_001106652.1 hypothetical protein -
CHN55_RS10265 1937836..1938120 + 285 WP_031590186.1 hypothetical protein -
CHN55_RS10270 1938182..1938400 + 219 WP_000005887.1 hypothetical protein -
CHN55_RS10275 1938896..1939096 - 201 WP_001059082.1 cold-shock protein -
CHN55_RS10280 1939453..1940139 - 687 WP_001641381.1 thermonuclease family protein -
CHN55_RS10285 1940480..1940956 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T107179 WP_000052076.1 NZ_CP030136:1936803-1936991 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T107179 NZ_CP030136:1936803-1936991 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT107179 WP_001059690.1 NZ_CP030136:1936514-1936774 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT107179 NZ_CP030136:1936514-1936774 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References