Detailed information of TA system TA107174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 813522..814310
• Replicon: chromosome
• Accession: NZ_CP030136
• Organism: Staphylococcus aureus strain S57

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CHN55_RS04335
• Protein ID: WP_129409664.1
• Coordinates: 813522..813983 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: CHN55_RS04340
• Protein ID: WP_000333630.1
• Coordinates: 813996..814310 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHN55_RS04310	808566..809822	+	1257	WP_129409662.1	aminopeptidase	-
CHN55_RS04315	809912..810442	+	531	WP_000184383.1	acyl-CoA thioesterase	-
CHN55_RS04320	810702..811847	-	1146	WP_057511308.1	radical SAM/CxCxxxxC motif protein YfkAB	-
CHN55_RS04325	811892..812938	-	1047	WP_031886361.1	site-specific integrase	-
CHN55_RS04330	813000..813503	-	504	WP_129409663.1	hypothetical protein	-
CHN55_RS04335	813522..813983	-	462	WP_129409664.1	toxin	Toxin
CHN55_RS04340	813996..814310	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	Antitoxin
CHN55_RS04345	814462..814698	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
CHN55_RS04350	814712..815488	+	777	WP_001148544.1	Rha family transcriptional regulator	-
CHN55_RS04355	815517..815660	+	144	WP_000939498.1	hypothetical protein	-
CHN55_RS04360	815670..816323	-	654	WP_031886359.1	hypothetical protein	-
CHN55_RS04365	816395..816616	+	222	WP_000594790.1	hypothetical protein	-
CHN55_RS04370	816609..816770	+	162	WP_000066017.1	DUF1270 domain-containing protein	-
CHN55_RS04375	816863..817165	+	303	WP_000165363.1	DUF2482 family protein	-
CHN55_RS04380	817170..817430	+	261	WP_031886358.1	DUF1108 family protein	-
CHN55_RS04385	817440..817661	+	222	WP_000815401.1	DUF2483 family protein	-
CHN55_RS04390	817654..818277	+	624	WP_000139720.1	DUF1071 domain-containing protein	-
CHN55_RS04395	818277..818705	+	429	WP_031886357.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	811892..858679	46787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18044.43 Da
• Isoelectric Point: 4.6915

>T107174 WP_129409664.1 NZ_CP030136:c813983-813522 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGAHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T107174 NZ_CP030136:c813983-813522 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATACAAAAAGATATATGGTATTGGAGCTC
ACTATGGCGAGTATTCTATTACATTTGAGCCATTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT107174 WP_000333630.1 NZ_CP030136:c814310-813996 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT107174 NZ_CP030136:c814310-813996 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0