Detailed information of TA system TA107173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 665550..666079
• Replicon: chromosome
• Accession: NZ_CP030136
• Organism: Staphylococcus aureus strain S57

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CHN55_RS03530
• Protein ID: WP_000621175.1
• Coordinates: 665717..666079 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CHN55_RS03525
• Protein ID: WP_000948331.1
• Coordinates: 665550..665720 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHN55_RS03495	660586..661146	+	561	WP_001092410.1	K(+)-transporting ATPase subunit C	-
CHN55_RS03500	661355..661834	+	480	WP_031590204.1	hypothetical protein	-
CHN55_RS03505	661827..663410	+	1584	WP_001294626.1	PH domain-containing protein	-
CHN55_RS03510	663397..663888	+	492	WP_072353916.1	PH domain-containing protein	-
CHN55_RS03515	663892..664251	+	360	WP_000581197.1	holo-ACP synthase	-
CHN55_RS03520	664317..665465	+	1149	WP_001281154.1	alanine racemase	-
CHN55_RS03525	665550..665720	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CHN55_RS03530	665717..666079	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CHN55_RS03540	666452..667453	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
CHN55_RS03545	667572..667898	+	327	WP_001052491.1	anti-sigma factor antagonist	-
CHN55_RS03550	667900..668379	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
CHN55_RS03555	668354..669124	+	771	WP_001041102.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T107173 WP_000621175.1 NZ_CP030136:665717-666079 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T107173 NZ_CP030136:665717-666079 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT107173 WP_000948331.1 NZ_CP030136:665550-665720 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT107173 NZ_CP030136:665550-665720 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1