Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 645825..646339 Replicon chromosome
Accession NZ_CP030136
Organism Staphylococcus aureus strain S57

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag CHN55_RS03440 Protein ID WP_000581793.1
Coordinates 646130..646339 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag CHN55_RS03435 Protein ID WP_000138932.1
Coordinates 645825..646118 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHN55_RS03405 641287..641928 + 642 WP_000483155.1 thiamine phosphate synthase -
CHN55_RS03410 642014..642886 + 873 WP_000725802.1 membrane protein insertase YidC -
CHN55_RS03425 643500..644147 - 648 WP_031590210.1 HD domain-containing protein -
CHN55_RS03430 644175..645659 - 1485 WP_000571549.1 cardiolipin synthase -
CHN55_RS03435 645825..646118 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
CHN55_RS03440 646130..646339 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
CHN55_RS03445 646467..646604 + 138 WP_000828354.1 hypothetical protein -
CHN55_RS03450 646867..648069 - 1203 WP_031590208.1 rod shape-determining protein RodA -
CHN55_RS03455 648387..649457 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
CHN55_RS03460 649472..650830 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T107172 WP_000581793.1 NZ_CP030136:646130-646339 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T107172 NZ_CP030136:646130-646339 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT107172 WP_000138932.1 NZ_CP030136:645825-646118 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT107172 NZ_CP030136:645825-646118 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References