Detailed information of TA system TA107149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2028876..2029440
• Replicon: chromosome
• Accession: NZ_CP030126
• Organism: Indioceanicola profundi strain SCSIO 08040

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DOL89_RS09700
• Protein ID: WP_119680351.1
• Coordinates: 2029261..2029440 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DOL89_RS09695
• Protein ID: WP_119678964.1
• Coordinates: 2028876..2029250 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOL89_RS09685	2024628..2026100	-	1473	WP_119678962.1	DUF3369 domain-containing protein	-
DOL89_RS09690	2026272..2028836	+	2565	WP_119678963.1	cation:proton antiporter	-
DOL89_RS09695	2028876..2029250	-	375	WP_119678964.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DOL89_RS09700	2029261..2029440	-	180	WP_119680351.1	type II toxin-antitoxin system HicA family toxin	Toxin
DOL89_RS09705	2029490..2031091	-	1602	WP_119680352.1	HAMP domain-containing histidine kinase	-
DOL89_RS09710	2031178..2032023	-	846	WP_119678965.1	response regulator transcription factor	-
DOL89_RS09715	2031929..2032618	-	690	WP_119678966.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6659.87 Da
• Isoelectric Point: 11.8650

>T107149 WP_119680351.1 NZ_CP030126:c2029440-2029261 [Indioceanicola profundi]
MRGADLIRELKAAGWMPDRVRGSHHVFKHPDRPGHLVVPHPKKDLGTGLMTAIRMQARL

Nucleotide

• Length: 180 bp

>T107149 NZ_CP030126:c2029440-2029261 [Indioceanicola profundi]
ATGAGGGGCGCGGACCTGATACGCGAGTTGAAAGCAGCAGGTTGGATGCCGGATCGGGTCCGCGGGTCCCATCACGTCTT
CAAACATCCTGATCGTCCCGGCCACTTGGTTGTACCGCACCCGAAGAAAGACCTCGGGACCGGGCTTATGACGGCGATCC
GCATGCAGGCGAGGCTCTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13073.68 Da
• Isoelectric Point: 4.1100

>AT107149 WP_119678964.1 NZ_CP030126:c2029250-2028876 [Indioceanicola profundi]
MRYPIAIEPGSGETAFGVVVHDLPGCFSAGESLDEAIQAAEEAAAAWVDAALDAVTAVPAPSSLDAIRANPDFKGWTFGF
MTVDPALLDDTVERINVSLPRRVLRRLDSLAQAAGETRSGYLPS

Nucleotide

• Length: 375 bp

>AT107149 NZ_CP030126:c2029250-2028876 [Indioceanicola profundi]
ATGCGCTATCCCATCGCGATCGAACCGGGCAGCGGGGAAACAGCTTTTGGCGTCGTAGTGCACGATCTGCCAGGGTGCTT
CTCGGCCGGCGAAAGCCTGGACGAAGCCATTCAAGCTGCCGAGGAGGCTGCGGCGGCCTGGGTCGACGCGGCCCTGGATG
CCGTCACCGCTGTTCCGGCCCCCTCGTCACTGGACGCGATCCGTGCGAACCCGGATTTCAAAGGCTGGACATTCGGCTTC
ATGACTGTCGACCCCGCATTGCTGGACGACACGGTGGAGCGGATCAATGTCTCTCTGCCACGGCGGGTATTGCGCCGGCT
CGACAGTTTGGCACAGGCGGCCGGCGAAACCAGGTCCGGCTACTTGCCAAGCTGA