Detailed information of TA system TA107148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1945041..1945606
• Replicon: chromosome
• Accession: NZ_CP030126
• Organism: Indioceanicola profundi strain SCSIO 08040

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DOL89_RS09255
• Protein ID: WP_119678885.1
• Coordinates: 1945041..1945412 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DOL89_RS09260
• Protein ID: WP_119678886.1
• Coordinates: 1945409..1945606 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOL89_RS09210	1940042..1940404	-	363	WP_119678877.1	hydroxyisourate hydrolase	-
DOL89_RS09215	1940564..1941094	+	531	WP_162937419.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
DOL89_RS09220	1941150..1941434	+	285	WP_119678879.1	hypothetical protein	-
DOL89_RS09225	1941431..1941643	+	213	WP_119678880.1	hypothetical protein	-
DOL89_RS09230	1941640..1942560	-	921	WP_119678881.1	LysR family transcriptional regulator	-
DOL89_RS09235	1942601..1943176	-	576	WP_119678882.1	HupE/UreJ family protein	-
DOL89_RS09240	1943188..1943832	-	645	WP_119678883.1	urease accessory protein UreG	-
DOL89_RS09245	1943829..1944509	-	681	WP_119680343.1	urease accessory protein UreF	-
DOL89_RS09250	1944499..1945041	-	543	WP_119678884.1	urease accessory protein UreE	-
DOL89_RS09255	1945041..1945412	-	372	WP_119678885.1	type II toxin-antitoxin system VapC family toxin	Toxin
DOL89_RS09260	1945409..1945606	-	198	WP_119678886.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DOL89_RS09265	1945669..1947381	-	1713	WP_119678887.1	urease subunit alpha	-
DOL89_RS09270	1947385..1947717	-	333	WP_119678888.1	urease subunit beta	-
DOL89_RS09275	1947729..1948031	-	303	WP_119678889.1	urease subunit gamma	-
DOL89_RS09280	1948050..1948952	-	903	WP_119678890.1	urease accessory protein UreD	-
DOL89_RS24825	1948952..1949110	-	159	WP_162937420.1	hypothetical protein	-
DOL89_RS09285	1949179..1950081	-	903	WP_205574552.1	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13571.77 Da
• Isoelectric Point: 6.2172

>T107148 WP_119678885.1 NZ_CP030126:c1945412-1945041 [Indioceanicola profundi]
MILVDSSVWIDHLRARDEVLMSLLVERRVAGHPFILGEVALGSIANRDVVVEQLKELPQLAVAEDAEVMALIDRHRLFGR
GIGYVDAHLLAAVRLTPAAGIWTRDRRLHQAAVELDVASGVLH

Nucleotide

• Length: 372 bp

>T107148 NZ_CP030126:c1945412-1945041 [Indioceanicola profundi]
ATGATCCTGGTCGACAGCTCCGTCTGGATCGACCATCTCCGCGCACGGGATGAGGTGCTGATGTCCCTCCTTGTAGAACG
CCGGGTCGCAGGGCACCCCTTCATCCTGGGTGAGGTCGCATTGGGAAGCATCGCCAACCGCGATGTCGTGGTGGAGCAGC
TAAAGGAATTGCCCCAACTCGCGGTCGCGGAGGATGCGGAAGTCATGGCGCTGATCGACCGGCATCGCCTGTTCGGACGG
GGCATCGGATATGTGGATGCGCATCTTCTTGCCGCTGTTCGTTTGACGCCCGCGGCCGGCATCTGGACCCGCGACAGGCG
CCTGCATCAGGCGGCGGTCGAGCTGGATGTGGCCTCGGGAGTGCTGCATTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7124.15 Da
• Isoelectric Point: 10.0823

>AT107148 WP_119678886.1 NZ_CP030126:c1945606-1945409 [Indioceanicola profundi]
MRTTVTLDDELVAKARRYTEIQETSALLNKALKTLVELEASRRLALLGGSDPAATAAPRRRPEST

Nucleotide

• Length: 198 bp

>AT107148 NZ_CP030126:c1945606-1945409 [Indioceanicola profundi]
ATGCGCACCACTGTGACCCTGGATGATGAGCTGGTGGCCAAGGCCCGGCGCTATACCGAAATACAGGAGACATCCGCTCT
GCTGAACAAAGCGCTGAAGACCCTGGTCGAACTGGAGGCGTCCCGCCGGCTGGCCCTATTGGGCGGCAGCGATCCCGCCG
CGACCGCCGCTCCTCGCCGGCGGCCGGAATCCACATGA