Detailed information of TA system TA107147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1709237..1709933
• Replicon: chromosome
• Accession: NZ_CP030126
• Organism: Indioceanicola profundi strain SCSIO 08040

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DOL89_RS08140
• Protein ID: WP_162937394.1
• Coordinates: 1709237..1709671 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DOL89_RS08145
• Protein ID: WP_119678692.1
• Coordinates: 1709673..1709933 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOL89_RS08110	1704854..1705792	-	939	WP_119678686.1	cell envelope integrity protein TolA	-
DOL89_RS08115	1705837..1706292	-	456	WP_119678687.1	protein TolR	-
DOL89_RS08120	1706296..1707015	-	720	WP_119680319.1	protein TolQ	-
DOL89_RS08125	1707051..1707539	-	489	WP_119678688.1	YbgC/FadM family acyl-CoA thioesterase	-
DOL89_RS08130	1707532..1708620	-	1089	WP_119678689.1	Holliday junction branch migration DNA helicase RuvB	-
DOL89_RS08135	1708617..1709240	-	624	WP_119678690.1	Holliday junction branch migration protein RuvA	-
DOL89_RS08140	1709237..1709671	-	435	WP_162937394.1	type II toxin-antitoxin system VapC family toxin	Toxin
DOL89_RS08145	1709673..1709933	-	261	WP_119678692.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DOL89_RS08150	1709997..1710524	-	528	WP_119678693.1	crossover junction endodeoxyribonuclease RuvC	-
DOL89_RS08155	1710539..1711285	-	747	WP_119678694.1	YebC/PmpR family DNA-binding transcriptional regulator	-
DOL89_RS08160	1711475..1712239	-	765	WP_205574657.1	enoyl-ACP reductase FabI	-
DOL89_RS08165	1712236..1713369	-	1134	WP_119680320.1	tRNA 2-thiouridine(34) synthase MnmA	-
DOL89_RS08170	1713540..1714313	+	774	WP_119678695.1	M48 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15800.97 Da
• Isoelectric Point: 5.1498

>T107147 WP_162937394.1 NZ_CP030126:c1709671-1709237 [Indioceanicola profundi]
MRIVLDTSAILAVGFDEADADTYQSALEMLHRPFISAVTLFEMRTVLAFRKGQDVLTTMELAFARWNTEVVPFDEGQASA
AFQAYRRYGKGTGHRAKLNFADCAAYALARSVDAPLLFNGNDFNHTDVTPALPLLVPEAGGRTL

Nucleotide

• Length: 435 bp

>T107147 NZ_CP030126:c1709671-1709237 [Indioceanicola profundi]
ATGCGGATCGTTCTCGACACTTCCGCGATTCTGGCGGTCGGCTTTGATGAGGCTGACGCGGATACCTATCAATCCGCTCT
TGAGATGCTGCACCGGCCCTTCATCTCCGCCGTCACGCTGTTCGAGATGCGGACGGTCCTGGCATTCCGGAAGGGGCAGG
ACGTGCTGACGACGATGGAGCTGGCATTTGCGCGCTGGAACACGGAAGTCGTGCCTTTCGACGAAGGGCAGGCGTCCGCC
GCTTTCCAGGCCTATCGCCGCTACGGCAAGGGAACCGGTCATCGTGCGAAGTTGAACTTCGCCGATTGTGCAGCCTATGC
GTTGGCGCGGTCGGTGGATGCGCCGCTGCTTTTCAATGGTAACGACTTCAACCATACCGACGTGACCCCGGCTCTGCCTC
TGCTGGTGCCCGAGGCGGGAGGGAGGACCTTATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9921.16 Da
• Isoelectric Point: 4.4160

>AT107147 WP_119678692.1 NZ_CP030126:c1709933-1709673 [Indioceanicola profundi]
MALNIKSDEAEQAVRRLAELTGESITETIRIAAEERLARLEATRQQAELRRRADIRELLEQVRRAPVLDNRPEDEILGYD
DLGMFD

Nucleotide

• Length: 261 bp

>AT107147 NZ_CP030126:c1709933-1709673 [Indioceanicola profundi]
ATGGCGCTGAACATCAAATCCGATGAGGCCGAGCAGGCCGTCCGGCGGCTTGCGGAGCTGACGGGGGAGAGCATCACCGA
AACCATCCGAATCGCGGCGGAGGAGCGGCTGGCGCGGCTTGAGGCAACACGCCAGCAGGCGGAGCTCCGGCGTCGCGCGG
ATATCCGGGAGCTTCTGGAGCAGGTCCGCAGGGCGCCGGTCCTGGACAACCGCCCGGAGGACGAAATCCTGGGCTATGAC
GATCTCGGGATGTTCGACTGA