Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2024838..2025444 Replicon chromosome
Accession NZ_CP030125
Organism Streptococcus suis strain HA1003

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DP112_RS10050 Protein ID WP_114866913.1
Coordinates 2024838..2025167 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag DP112_RS10055 Protein ID WP_105249269.1
Coordinates 2025157..2025444 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP112_RS10035 2020790..2022520 - 1731 WP_164503937.1 hypothetical protein -
DP112_RS10040 2022728..2023630 - 903 WP_114867039.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DP112_RS10045 2023624..2024778 - 1155 WP_114866912.1 MBL fold metallo-hydrolase -
DP112_RS10050 2024838..2025167 - 330 WP_114866913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DP112_RS10055 2025157..2025444 - 288 WP_105249269.1 toxin-antitoxin system antitoxin subunit Antitoxin
DP112_RS10060 2025542..2025910 - 369 WP_024391609.1 hypothetical protein -
DP112_RS10065 2025903..2026493 - 591 WP_164503938.1 ribonuclease M5 -
DP112_RS10070 2026456..2027238 - 783 WP_114867041.1 TatD family hydrolase -
DP112_RS10075 2027323..2027460 - 138 WP_002939016.1 50S ribosomal protein L34 -
DP112_RS10080 2027628..2028623 - 996 WP_013730624.1 protein jag -
DP112_RS10085 2028643..2029455 - 813 WP_114866914.1 YidC/Oxa1 family membrane protein insertase -
DP112_RS10090 2029439..2029798 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12580.55 Da        Isoelectric Point: 7.1991

>T107145 WP_114866913.1 NZ_CP030125:c2025167-2024838 [Streptococcus suis]
MEFESYSVMLAPAVEKELAAIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQVDPPHLTRGYVIGKD
YIVLYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T107145 NZ_CP030125:c2025167-2024838 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATGCTTGCTCCTGCAGTGGAGAAGGAATTGGCAGCTATTTATGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTTGAAGCTTTGGAGAGTTTGCAGATTTTTCCTGAAC
GTGGTTTTAACGCTGATAACCGTTTTGGTAAGCAGGTAGACCCGCCACATCTAACCCGAGGTTACGTTATTGGAAAAGAT
TACATCGTCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGACACCTTTTTGCGACCAAGAGTGATTATGTAAAGTT
ATTGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.4616

>AT107145 WP_105249269.1 NZ_CP030125:c2025444-2025157 [Streptococcus suis]
MLTIKKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT107145 NZ_CP030125:c2025444-2025157 [Streptococcus suis]
TTGCTAACTATAAAGAAAGATGCCCAAGTAAATTTTAAAACCGACTCTAGACTTTTAGAGAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATTGCTGTAAAAAATGAGTTGCCCATTCTGA
CTGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATTCAGGAAAATCAGCAGGCGATTGAGGCA
GGTCATGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References