Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 645733..646219 Replicon chromosome
Accession NZ_CP030125
Organism Streptococcus suis strain HA1003

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8G620
Locus tag DP112_RS03335 Protein ID WP_024385504.1
Coordinates 645950..646219 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag DP112_RS03330 Protein ID WP_002938604.1
Coordinates 645733..645960 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP112_RS03305 641312..641857 - 546 WP_002941732.1 NAD(P)H-dependent oxidoreductase -
DP112_RS03310 641920..642369 - 450 WP_114866336.1 MarR family transcriptional regulator -
DP112_RS03315 642583..643080 + 498 WP_105134088.1 DUF5590 domain-containing protein -
DP112_RS03320 643077..644258 + 1182 WP_114866337.1 pyridoxal phosphate-dependent aminotransferase -
DP112_RS03325 644273..645619 + 1347 WP_014638198.1 asparagine--tRNA ligase -
DP112_RS03330 645733..645960 + 228 WP_002938604.1 hypothetical protein Antitoxin
DP112_RS03335 645950..646219 + 270 WP_024385504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DP112_RS03340 646335..647654 + 1320 WP_114866338.1 MATE family efflux transporter -
DP112_RS03345 647838..648215 + 378 WP_029171852.1 RidA family protein -
DP112_RS03350 648237..649124 + 888 WP_024412169.1 RNase adapter RapZ -
DP112_RS03355 649121..650095 + 975 WP_024400159.1 YvcK family protein -
DP112_RS03360 650092..651009 + 918 WP_105151201.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 640666..641130 464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10463.52 Da        Isoelectric Point: 10.3192

>T107143 WP_024385504.1 NZ_CP030125:645950-646219 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GYRKEIYKK

Download         Length: 270 bp

>T107143 NZ_CP030125:645950-646219 [Streptococcus suis]
ATGGCCTATAAACTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAAAATCCAAGACAGTTTGGCAAGGCCTTGGTTGGAGATTATAAGGGCC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTGATTTGCGATATTATTGATAACAAAATGGTCATCCTAGCTCTTGAAATC
GGATACCGGAAAGAAATCTATAAAAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT107143 WP_002938604.1 NZ_CP030125:645733-645960 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT107143 NZ_CP030125:645733-645960 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGGTTAAACGATGCAGAAGAAGAAATCTTCAGAAGCTATGCCATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8G620

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References